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CRUK Studentship - Odom


The Cancer Research UK Cambridge Institute, a department of the University of Cambridge hosts research ranging from basic cancer and computational biology through to translational research and clinical application. Postgraduate students play a pivotal role in the continuing success of our research programmes and the Institute provides an excellent opportunity to start a research career in an environment committed to training outstanding cancer research scientists of the future.

Dr Duncan Odom (DO) is seeking a student to work on Epigenetic mechanisms of increased transcriptional variability during ageing.

The goal of this PhD project is to establish and test the mechanisms that cause this increase in transcriptional variability during ageing. Mapping the active enhancers, promoters, and transcription in purified populations of cells from younger and older animals will allow differences in regulatory activity to be quantified. Candidate regulatory regions will then be tested for function by creating genetically engineered mouse models. There is also the possibility of pursuing a comparative functional genomics approach in the same purified cell type in different species, to evaluate how conserved or divergent the mechanisms underlying ageing are.

Preferred skills/knowledge - Excellent academic training in modern genetics and genomics is a prerequisite. A research master's degree, as well as good familiarity with commonly-used experimental genomics techniques such as RNA-seq and ChIP-seq would be highly desirable. Prior experience with single cell technologies, such as Fluidigm or Drop-seq systems would be advantageous but not necessary.

Funding - This studentship is funded by Cancer Research UK and includes full funding for University and College fees and in addition, a stipend of £19,000 per annum, initially for 3 years, with funding for a further year possible as required.

Eligibility - No nationality restrictions apply to this Cancer Research UK funded studentship. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.

How to apply - Please follow the instructions on the following webpage: (http://www.graduate.study.cam.ac.uk/courses/directory/cvcrpdmsc/apply)

Notes on completing the application form - Course start date: 01 October 2018

Completing the 'Research section' - In the 'Research Title' textbox, if you are only applying for consideration by one supervisor, insert their project title. If you wish your application to be considered by more than one, insert 'Cancer research'. If you are applying for consideration by more than one supervisor, in the 'Research Summary' textbox, please insert the project title(s) being offered by the Supervisor(s) you wish to consider your application. Also in the 'Research Supervisor' textbox please insert the initials of the Supervisor(s) you wish to consider your application. Please also describe your research experience in the appropriate textbox.

Completing the 'Finance' section - We know that you are applying for a Cancer Research UK Studentship. If you have not already applied for other source(s) of funding, please tick 'no'. Then please tick 'yes' to be considered for Cambridge scholarships, and you will be considered for these in addition to a Cancer Research UK Studentship. You are not eligible for AHRC funding.

Course Specific Questions - Please add a Covering Letter as the last two pages of your CV. Your Covering Letter should explain why you wish to be considered for the studentship and describe the qualities and experience you would bring to the role. You will be asked to upload your CV (under Course Specific Questions).

Please quote reference SW13455 on your application and in any correspondence about this vacancy.

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