University of Cambridge

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CRUK Studentship - Marioni

The Cancer Research UK Cambridge Institute, a department of the University of Cambridge hosts research ranging from basic cancer and computational biology through to translational research and clinical application. Postgraduate students play a pivotal role in the continuing success of our research programmes and the Institute provides an excellent opportunity to start a research career in an environment committed to training outstanding cancer research scientists of the future.

Dr John Marioni (JM) is seeking a student to work on Computational methods for spatial transcriptomics.

Project details - Dr Marioni offers a PhD position to explore spatial heterogeneity in gene expression profiles at single-cell resolution. The project will exploit recently developed spatial transcriptomics technologies to model how heterogeneity in expression varies both between and within individual cells. The Marioni lab has pioneered the development of computational methods for single cell genomics and has applied these methods to understand how variability in expression between cells underlies different biological processes, including early development and cancer. The lab is based both at CRUK CI and at EMBL-EBI and has excellent links with researchers across both institutes. Additionally, Dr Marioni co-chairs the analysis working group of the Human Cell Atlas project as well as co-ordinating the European contribution to the Data Coordination Platform.

Preferred skills/knowledge - The successful applicant will have/or expect to gain a degree in a quantitative field like mathematics, statistics, physics, engineering, bioinformatics, or computer science. The applicant should have a good biological background and excellent computing skills. The atmosphere within the lab and at CRUK CI more generally is very collaborative - hence, good communication skills are key.

Funding - This studentship is funded by Cancer Research UK and includes full funding for University and College fees and in addition, a stipend of £19,000 per annum, initially for 3 years, with funding for a further year possible as required.

Eligibility - No nationality restrictions apply to this Cancer Research UK funded studentship. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.

How to apply - Please follow the instructions on the following webpage: (

Notes on completing the application form - Course start date: 01 October 2018.

Completing the 'Research section' - In the 'Research Title' textbox, if you are only applying for consideration by one supervisor, insert their project title. If you wish your application to be considered by more than one, insert 'Cancer research'. If you are applying for consideration by more than one supervisor, in the 'Research Summary' textbox, please insert the project title(s) being offered by the Supervisor(s) you wish to consider your application. Also in the 'Research Supervisor' textbox please insert the initials of the Supervisor(s) you wish to consider your application. Please also describe your research experience in the appropriate textbox.

Completing the 'Finance' section - We know that you are applying for a Cancer Research UK Studentship. If you have not already applied for other source(s) of funding, please tick 'no'. Then please tick 'yes' to be considered for Cambridge scholarships, and you will be considered for these in addition to a Cancer Research UK Studentship. You are not eligible for AHRC funding.

Course Specific Questions - Please add a Covering Letter as the last two pages of your CV. Your Covering Letter should explain why you wish to be considered for the studentship and describe the qualities and experience you would bring to the role. You will be asked to upload your CV (under Course Specific Questions).

Please quote reference SW13450 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information