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PhD Studentship: Single Molecule Imaging of T-cell Triggering


Applications are invited for a PhD studentship in the group led by Professor David Klenerman, in collaboration with Professor Simon Davis at Oxford, that exploits single molecule imaging to determine the molecular basis of the triggering of T-cells, the process that underpins the adaptive immune response (see Nature Immunology 17, 574 (2016)). The imaging is based on single molecule fluorescence using home-built total internal reflection fluorescence microscopes and a novel light-sheet microscope and includes the use of quantum dots to map the separation between the cell and surface at high resolution. Experiments will be performed on model bilayers and substrates as well as at cell-cell contacts and analysed using bespoke software. This project will suit a student trained in chemistry, physics or biophysics who wants to apply physical methods to a fundamental biological problem. No prior experience in biology or immunology is required.

Applicants must have (or expect to obtain) at least the equivalent of a UK upper second class honours degree (and preferably a Masters) in chemistry, physics, biophysics or other relevant discipline.

The studentship is available from October 2018, and provides a maintenance grant and tuition fees at the UK/EU rate. Non-EU nationals will be considered only if they can cover the differential for overseas tuition fees.

Applications should include a cover letter, a CV, detailed academic transcripts and the contact details for at least two academic referees, and should be emailed to: Professor David Klenerman (dk10012@cam.ac.uk) to whom any informal enquiries can be addressed.

If you wish to be considered for any other available studentships in the Chemistry Department, you must also apply online via the University Applicant Portal and complete the Chemistry Department Application form (further information at http://www.ch.cam.ac.uk/pgapp). Please note that there is an application fee.

Information about research in the Department of Chemistry is given at: http://www.ch.cam.ac.uk

Please quote reference MA13403 on your application and in any correspondence about this vacancy.