The Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments. The Institute currently comprises 29 research groups based across 6 sites in Cambridge. In 2018 all researchers will move to a new building on the Cambridge Biomedical Campus.
Applications are invited to join a dynamic team led by Dr Sanjay Sinha at the Cambridge Stem Cell Institute (http://www.stemcells.cam.ac.uk/research/pis/sinha). We have pioneered the generation of vascular smooth muscle cells from human embryonic and induced pluripotent stem cells (iPSCs) via different embryonic lineages (Cheung et al., Nature Biotechnology 2012;30:165-73, Iyer et al., Development 2015;142:1528-41). Recently we used this approach to establish an in vitro model of vascular disease in Marfan syndrome using patient-derived iPSCs, and highlighted a novel role for p38 MAP kinase in regulating smooth muscle cell death (Granata et al., Nature Genetics 2017;49:97-109).
The focus of this exciting disease oriented project will be to identify how embryonic lineage contributes to aortic disease and to develop further iPSC based models of aortic aneurysms (Ehlers-Danlos syndrome and ACTA2). The successful applicant will also work with Dr Paul Bertone for in depth bioinformatics analyses of these in vitro models (RNA-seq & ChIP-seq).
The advertised position is funded through a British Heart Foundation Program Grant for 5 years, thus allowing a highly motivated scientist to make a substantial contribution to the development of new treatments for aortic diseases and establish a career in cardiovascular regenerative medicine.
You will have a PhD (or equivalent) with an extensive background in cell and molecular biology, experience with bioinformatics and a strong publication record. It is essential that you have excellent communication, writing and organisational skills and the ability to work collaboratively. Prior experience with human ES/iPS cells will be advantageous.
Informal enquiries to Dr Sanjay Sinha (firstname.lastname@example.org) are encouraged.
Fixed-term: The funds for this post are available until 1 October 2022 in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing date for applications is the 2nd October 2017, with interviews yet to be confirmed by the department.
Please quote reference RC13227 on your application and in any correspondence about this vacancy.
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