The MRC wishes to appoint a postdoctoral scientist to join Professor John Walker's ATP Synthase research group in the Mitochondrial Biology Unit in Cambridge.
The post-holder will work on the structure and mechanism of ATP synthases. The aim is to understand the molecular mechanism of the generation of rotation in the enzyme. Understanding rotation driven by the transmembrane proton-motive force is an unsolved problem dependent on defining the molecular mechanism for translocation of protons through the membrane domain of the enzyme. Cryo-electron microscopic approaches will be employed to follow up on our recently published structures of the bovine and fungal enzymes solved by cryo-EM where the rotary mechanism of the enzyme provided additional challenges to the processing of the data. The post-holder will work with other scientists to establish the mechanism of proton translocation and its coupling to the rotary mechanism of the mitochondrial ATP synthase.
Candidates will have a PhD (or equivalent) in biochemistry, biophysics or molecular biology, and a track record of related research achievements. Previous experience with all of the following is essential: isolation of mitochondrial ATP synthases, and cryo-electron microscopy and single particle analysis.
The MRC Mitochondrial Biology Unit is a world-renowned centre for research in respiratory enzymes. Additional information can be found at www.mrc-mbu.cam.ac.uk.
Fixed-term: The funds for this post are available for 18 months in the first instance.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
The closing date for applications is 24th August 2017. Interview dates are to be confirmed.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference SM13049 on your application and in any correspondence about this vacancy.
The University values diversity and is committed to equality of opportunity.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.