A Research Associate vacancy exists in Dr Roisin Owen's group at the Department of Chemical Engineering and Biotechnology.
The role holder will work on a project to develop integrated organic bioelectronic sensing technologies to improve biosensing in real-world conditions. Electrical, label-free sensing of cellular and subcellular elements including lipid bilayers, secreted metabolites, proteins and nucleic acids, as well as physiological states such as redox state or pH, is known to be advantageous with regards to speed and sensitivity, and indeed the integration of biosensors with microelectronic devices has brought about multiplexed capabilities as well as enabling miniaturization and automation. However, some key issues still impede their practical implementation in a clinical setting. Recently, the organic electrochemical transistor (OECT) has drawn considerable attention as sensing element. OECTs have proven to outperform state-of-the-art devices such as electrodes, and have been used in a wide variety of biological applications, including metabolite sensing.
The role holder will develop an in vitro electronic platform for sensitive and accurate metabolite sensing from live cells. Based on the OECT technology, the candidate will develop multi-parameter sensing devices capable of highly sensitive and specific detection of multiple parameters such as lactate, glucose, oxygen and pH from cell culture extracts. In collaboration with researchers at the University and abroad, the role holder will have the responsibility to design and fabricate devices based on existing materials and protocols, but also incorporating novel materials that may come down the pipeline, and also to develop biofunctionalization protocols for adapted sensing of specific parameters.
The ideal candidate will have a PhD in Chemical Engineering, materials science, or a related scientific discipline, and experience in bioelectronics with a focus on organic bioelectronics. The candidate will have the responsibility to design, fabricate and iteratively optimize organic electronic devices. Previous experience in cleanroom based microfabrication techniques, organic electronics, and cell based biosensing are required. This is a multidisciplinary project and the successful candidate should be willing to and capable of interacting with team members from disciplines ranging from cell biology to chemistry to physics.
More information about the Department can be found here: http://www.ceb.cam.ac.uk/
Fixed-term: The funds for this post are available for 12 months in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Applicants should ensure their application is complete and submitted by Midnight on the closing date.
Please quote reference NQ12702 on your application and in any correspondence about this vacancy.
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