University of Cambridge

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Research Associate - Bioinformatics (Fixed Term)

Applications are invited for a Post-doctoral Research Associate position in the group of Dr Philip Wigge at the Sainsbury Laboratory, University of Cambridge. The research group studies temperature perception mechanisms in plants. Small changes in temperature have very large effects on plant growth and development. This is reflected in the transcriptome, which is highly responsive to temperature change. The Wigge group are using a combination of genetics, biochemistry, and next-generation sequencing approaches to understand the underlying mechanisms by which temperature controls development. This is an important basic question in biology as well as having considerable potential applications in biotechnology.

The group's work is revealing a complex interplay between transcription factors, chromatin and the temperature transcriptome, hence the large and growing need to increase the group's bioinformatics capacity to analyse large volumes of next generation sequencing data, including genome resequencing, RNA-seq and ChIP-seq.

Applicants should have, or be close to obtaining, a PhD in a relevant discipline (e.g. bioinformatics, computer science or scientific data analysis). Advanced knowledge and experience in bioinformatics is essential. Experience in RNA-seq and ChIP-seq data analysis is also desirable.

Candidates must have advanced knowledge and experience in the following areas: 1. scientific programming (with R or Python) 2. command-line tools for NGS analysis (e.g. Bowtie/Tophat/Cufflinks) 3. tools for peak calling, motif finding, and nucleosome mapping and, 4. NGS data management best practices.

The Wigge research group characterise a mixture of backgrounds in scientific disciplines, such as wet-bench biology, maths and computational analysis. This new bioinformatician role would work closely with the group to take an active part in the research and analysis. The successful candidate must be fascinated by science but not necessarily want the added responsibility of running their own research programme.

The post holder may be required to assist in the supervision of student projects, provide instructions to students and deliver seminars relating to their research area.

Good communication skills are essential as the post holder will need to work well in a team and collaborate with other researchers in the Institute.

The Laboratory provides a welcoming and collaborative environment with a wide-range of family-friendly benefits and development opportunities. More about the Sainsbury Laboratory and details of what the University offers to employees, can be found at:

The post is available immediately.

Fixed-term: The funds for this post are available until 31 March 2019 in the first instance.

Scientific enquiries apart from the formal application should be directed to Dr Philip Wigge at

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please ensure that you upload a copy of your full CV including a list of publications, a covering letter highlighting your suitability for the position and contact information of three referees.

Please quote reference PT12683 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information

Apply online