We have a Research Assistant position available in the laboratory of Dr Jamie Blundell in the Department of Oncology at the University of Cambridge. This post is funded by the Cancer Research UK Cambridge Centre.
We are looking for a researcher interested in helping to develop a novel in-situ DNA-barcode based lineage tracking tool for use in mammalian cell lines and mouse models. The successful candidate should have a degree (or equivalent) in the biological sciences, a background in molecular biology, and excellent communication skills.
The goal of the project associated with this post is to develop a more quantitative understanding of normal blood production by developing a quantitative lineage tracking tool. This tool is based on an inducible in-situ DNA barcoding technology that, combined with ultra-deep barcode sequencing, will have the potential to quantitatively track clone sizes in vivo. The first part of this project will involve a substantial amount of molecular biology and cloning to build the system into a cancer cell line, testing its efficiency, and performing power analyses to determine what data is required for mouse models. The second part of the project involves developing a mouse model with the in-situ barcoding tool and tracking the clonal dynamics from peripheral blood.
The Blundell lab is part of the Early Detection Programme of the Cancer Research UK Cambridge Centre at the University of Cambridge. The Blundell lab's research interests lie in quantitatively understanding the evolutionary dynamics of precancerous lesions and their progression to malignancy. An internationally recognised centre for cancer research, the Cancer Research UK Cambridge Centre is situated on Cambridge Biomedical Research Campus, with close ties to Addenbrooke's Hospital and a host of biotech companies. Our location affords our members ready access to tissue samples, cancer models, state of the art sequencing facilities, and the opportunity to forge collaborations with world class physicists, engineers, biologists and clinicians.
Informal enquiries are strongly encouraged, and should be directed to Jamie Blundell at firstname.lastname@example.org .
Fixed-term: The funds for this post are available for 1 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing date for applications is the 6th August 2017, with interviews yet to be confirmed by the department.
Please quote reference RD12654 on your application and in any correspondence about this vacancy.
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