Applications are invited for a Clinical Research Associate post, alongside a PhD in Medicine, to undertake research within the prestigious Experimental Medicine Initiative to Explore New Therapies (EMINENT) (www.ucl.ac.uk/eminent-consortium) programme; a unique partnership between UK academia and GSK aimed at increasing understanding of human disease mechanisms through experimental medicine. Jointly funded by the MRC and GSK, EMINENT affords investigators from the University of Cambridge, University College London (UCL), the University of Glasgow, the University of Newcastle and Imperial College London unprecedented access to GSK's un-licenced clinic-ready asset portfolio, technology and drug discovery expertise to enable experimental medicine studies aimed at enhancing mechanistic disease understanding and accelerating therapeutic advances in under-served disease areas. The development of a cadre of clinician scientists holding a rich base of knowledge and skills developed within a unique industrial-academic research environment represents a key objective for the EMINENT programme.
This innovative award is a partnership between the University of Cambridge, Division of Experimental Medicine and Immunotherapeutics within the Department of Medicine, and GlaxoSmithKline and provides an unrivalled opportunity to undertake high quality clinical research in the field of vasculitis, in collaboration with GSK. It will appeal to clinicians with a subspecialty interest and experience in rheumatology, renal medicine, vasculitis, Clinical Pharmacology and Clinical Immunology.
The project is an experimental medicine, mechanistic, multicentre, randomized, double blind, placebo-controlled investigative study, aiming to gain deeper insights into the pathogenesis of vasculitis and effects of combination therapy to aid in the development of novel biomarkers. The post-holder will play a central role in the smooth running of the clinical trial to GCP standards, and the experimental medicine aspect of the project, employing advanced research techniques such as flow cytometry, transcriptomics, in-vitro assays on peripheral blood samples and nasal and lymph node biopsy tissue samples. The applicant is expected to have clinical experience and interest in the field of vasculitis and immunology. Experience in the creation of flow-cytometry panels, running flow experiments and flow data analysis is desirable. Previous experience of vasculitis research, biomarker studies and clinical trials is required.
This project will provide the successful applicant with an opportunity to apply their strengths to vasculitis and experimental medicine, and a unique hands-on perspective of translational medicine.
The successful applicant will be offered the opportunity to spend time with GSK and academic collaborators and join a bespoke EMINENT Training Programme. The structured mentoring and training environment will allow the candidate to develop as an academic clinician with expertise in designing and conducting experimental medicine studies.
It is essential that the applicant is fully registered with the GMC, and desirable that they already hold a National Training Number.
For general queries on EMINENT please contact Professor Edwin Chilvers (Director), on 01223 762007; and for informal queries regarding this post, please contact Dr David Jayne on 01223 586796.
Fixed-term: The funds for this post are available for 3 years in the first instance.
This appointment requires an Honorary Clinical Contract.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Please ensure that you upload a covering letter, CV, list of publications, current and future research plans (two sides of A4 only) and the Clinical Research Associate additional information form in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing date for applications is the 31st July 2017, with interviews yet to be confirmed by the department.
Please quote reference RC12647 on your application and in any correspondence about this vacancy.
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