The Hannon laboratory at the CRUK Cambridge Institute is looking for a Research Associate to take part in an exciting new project combining molecular and cellular biology with novel microscopy and in-situ analysis techniques to produce single-cell resolution, molecularly annotated maps of tumours and other tissues. We expect this project to have a strong impact on the study of the tumour micro-environment, tumour heterogeneity and its evolution in time.
Our laboratory has a long standing interest in molecular biology and Cancer research, and a history of developing new tools to address cutting-edge questions in these fields (for a selected list of publications and research interests, see http://www.hannonlab.org/research/). For this project we are collaborating with a number of laboratories, both in Cambridge and all around the world, to merge advanced microscopy techniques capable of imaging entire organs at cellular resolution with novel in-situ phenotyping and genotyping techniques, in order to build maps describing the position, gene expression profile and evolutionary history of each cell in a tumour. We will apply these methods to mouse models of tumours and to human samples from the clinic. For more details on the project see http://www.hannonlab.org/tumours4d/.
We are looking for a molecular and cell biologist to lead the effort on the development of novel molecular methods for lineage tracing and contribute to improving and applying methods for in situ cell measurement.
The successful candidate should have (or be about to receive) a PhD (or equivalent) in a relevant discipline. They should have a strong background in molecular biology and cell biology, and skills in cloning, cell culture and histology. Experience in microscopy and in working with mouse models is a plus. Candidates are expected to be good communicators, independent thinkers, and have the ability to bring innovation to the field and find novel and out-of-the-box solutions to problems. They should be able to collaborate effectively with people with different backgrounds (mainly mathematics, chemistry and optics) to further the aims of this challenging project. The post is available immediately and will be held conjunctly in the Hannon laboratory and in the Innovation Lab, a cross-disciplinary group at the Cambridge Institute devoted to the development of cutting-edge technologies.
REFERENCES: 1.Serial two-photon tomography for automated ex vivo mouse brain imaging, Ragan, T et Al, Nat. Methods, 2012
2.Highly Multiplexed Subcellular RNA Sequencing in Situ, Lee, JH et Al, Science, 2014
3.RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells, Chen KH et Al, Science, 2015
4.Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry, Giesen et Al, Nature Methods, 2014
Fixed-term: The funds for this post are available for 3 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
The closing date for applications is 1 October 2017. Interview dates are to be confirmed. If you have any questions about this vacancy or the application process, please contact Mailboxfirstname.lastname@example.org
Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference SW12622 on your application and in any correspondence about this vacancy.
The University values diversity and is committed to equality of opportunity.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.