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Postdoctoral Research Associate: Elucidating the role of the nuclear envelope in centrosome assembly


Applications are invited for a BBSRC funded postdoctoral Research Associate position to join the lab of Dr. Paul Conduit in the Department of Zoology, located in central Cambridge. We study how microtubule formation is regulated in cells, including how microtubule organising centres (MTOCs) are assembled. The post-holder will use Drosophila melanogaster as an in vivo animal model system to follow up on our recent discover that the nuclear envelope may help regulate centrosome assembly. They will use CRISPR/HDR to generate a series of new fly strains, and then use advanced live-cell fluorescence imaging, including super-resolution imaging, and biochemistry to establish how the nuclear envelope helps regulate centrosome assembly. The project has important medical implications, as the misregulation of centrosome assembly has been linked with cancer progression and autosomal recessive primary microcephaly (MCPH).

The appointment will be for a period of up to three years starting 2nd October 2017, or as soon as possible thereafter.

Duties and responsibilities:

The post-holder will be expected to participate in the dissemination of research through publications and oral presentations both within the department and at conferences. They will also be expected to help advise and possibly train other members of the lab, as and when required.

Essential skills:

  • PhD in cell/developmental biology, or be close to the completion of their degree
  • Experience in fluorescent microscopy
  • Excellent analytic, design, and scientific skills
  • Good interpersonal skills and an ability to work as part of a team
  • The ability to organise time and work effectively, independently and responsibly

Desirable skills:

  • Prior experience in Drosophila and/or centrosome biology would be beneficial;
  • Prior experience in live-cell confocal (or similar) imaging, molecular biology and basic biochemistry would be an advantage.

Applications should include a C.V. and a brief statement of your scientific background and why you would like to join the lab.

Informal enquiries are welcomed and can be addressed to Dr. Paul Conduit ptc29@cam.ac.uk.

Please see the lab website for more information on our research http://conduitlab.zoo.cam.ac.uk/."

Fixed-term: The funds for this post are available for up to three years.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PF12439 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information

Apply online