A postdoctoral position is available to study the extrinsic modulation of intestinal proliferation in the research group of Golnar Kolahgar at the Department of Physiology, Development and Neuroscience at the University of Cambridge. The candidate is expected to hold a PhD in cellular, molecular or developmental biology.
Our goal is to identify the components of the extracellular space that contribute to maintaining and remodelling the adult intestine in response to various physiological conditions. We use the genetically tractable Drosophila gut as a paradigm to investigate cell fate decisions in vivo (e.g. Kolahgar et al, Dev Cell, 2015; Suijkerbuijk et al, Curr. Biol, 2016). The aim of this project is to explore how integrin signalling promotes intestinal stem cell proliferation and contributes to gut plasticity, using a combination of Drosophila genetics, lineage tracing and clonal analysis, confocal imaging and whole genome sequencing, thus experience with one or several of these techniques is required.
Essential skills: - working knowledge of general molecular and cell biological techniques and basic statistical tests - computer literacy (Microsoft office, Adobe Photoshop/Illustrator) - ability to work independently and as a good team player - proactive attitude - ability to communicate ideas effectively (in writing and verbally) - strong track record (with at least one first author publication in print or in preparation) in high quality scientific journals.
Desirable skills: - Although prior experience with Drosophila would be an advantage, full training is available. - Bioinformatics skills or prior experience of whole genome sequencing
Fixed-term: The funds for this post are available for 3 years in the first instance.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Please ensure that you upload your full Curriculum Vitae (CV) including list of relevant publications and a covering letter in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please quote reference PM12393 on your application and in any correspondence about this vacancy.
The University values diversity and is committed to equality of opportunity.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.