Applications are invited for a Post-doctoral Research Associate to join a dynamic research group. The group is led by Professor Christine Holt and studies the embryonic development of the visual system in order to elucidate the mechanisms involved in the formation and maintenance of functional nerve connections. The project will investigate the role of local protein synthesis and the RNA-binding proteins in axon survival in vivo. Ribosomal and RNA-binding proteins will be tested for a local role in axon and synaptic maintenance. The applicant should have expertise in molecular biology, single molecule translation imaging (SMTI) and knowledge of developmental neuroscience, neurodegenerative diseases and RNA biology. Techniques will include ribosome TRAP-IP from axonal compartments, live SMTI in axons in cultured retinal neurons and in Xenopus embryonic brains, electroporation and blastomere injection, functional gene knockdown studies, axon tracing, high-resolution optical imaging of translation reporters. Further details on research interests of the laboratory at www.pdn.cam.ac.uk/staff/holt/index.html.
Candidates should have a PhD in Biological Sciences, expertise in vertebrate embryology, developmental neuroscience, molecular biology, RNA biology, live imaging, particularly SMTI, primary neuronal culture, familiarity with the majority of techniques listed above and a high motivation to conduct research.
Fixed-term: The funds for this post are available for 12 months in the first instance.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Applications should include CV, publication list and a one-page research statement.
Please quote reference PM12130 on your application and in any correspondence about this vacancy.
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