The Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments.
We are looking for a self-motivated, reliable and well-trained post-doctoral researcher to join the research team of Dr. Maria Alcolea. Her team will investigate epithelial stem cell plasticity upon tissue regeneration and early cancer using oesophageal models.
In order to protect tissue integrity, epithelial cells have a significant ability to change and adapt their behaviour in response to changing tissue perturbations. Investigating the cellular and molecular mechanisms governing this dynamic cell behaviour, and the potential implications for early cancer development represents the main focus of the lab.
We will utilise a combination of in vivo lineage tracing techniques using genetic mouse models, ex vivo 3D organ cultures, and single cell transcriptional network analysis to investigate how mesenchymal activation impacts on epithelial cell behaviour during the initial stages of tumour formation.
We are looking for candidates who hold a PhD degree or will obtain a PhD degree within a year in the field of biochemistry /molecular and cell biology /developmental biology.
1) Research experience since completion of PhD. 2) Background in molecular and cell biology. 3) Knowledge in genetic animal models. 4) At least one publication with 1st authorship would be preferable, but not a requirement. 5) Previous experience with in vivo models, gene manipulation and expression profiling, confocal imaging, disease modelling and primary tissue culture methods would be highly advantageous, but not essential.
We are specifically looking for candidates that are collaborative, with effective communication skills and enjoy working in a team. Proven capacity to design, execute, and interpret your own experiments is essential.
Start date is flexible but can be as early as June 2017.
Fixed-term: The funds for this post are available for 2 years in the first instance. This post is based in the city of Cambridge, UK.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Please upload your Curriculum Vitae (CV) and a covering letter in the Upload section of the online application to supplement your application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Informal enquiries are also welcome via email: firstname.lastname@example.org .
Interviews will be held June 2017. If you have not been invited for interview by 23rd June 2017, you have not been successful on this occasion.
Please quote reference PS12012 on your application and in any correspondence about this vacancy.
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