Applications are invited for a Clinical Research Associate post within the Department of Medicine, Division of Experimental Medicine and Immunotherapeutics to work on the INTENSITY trial. This particular post offers an opportunity to undertake high quality Experimental Medicine research within an outstanding academic and clinical environment, and to work on innovative clinical research in the area of cardiovascular physiology/pharmacology. It will appeal to clinical trainees from a wide range of disciplines including Cardiology, Clinical Pharmacology and General Medicine.
The INTENSITY trial seeks to answer if there are limits to primary prevention in healthy volunteers by lowering LDL cholesterol, and the mechanisms by which secondary prevention in patients with established cardiovascular disease may benefit from even lower LDL levels using PCSK9 therapies. It involves two clinical studies: (1) an open label, parallel-group, single treatment, physiological study with the primary objective to test whether LDL cholesterol reduction with PCSK9 inhibition improves nitric oxide bioavailability as measured by forearm plethysmography in healthy individuals and (2) an open label, parallel-group study to test whether PCSK9 inhibtion reduces vascular inflammation on 18F-FDG PET/CT in patients with stable CV disease. This project will provide the successful applicant with an opportunity to apply their strengths to experimental medicine, cardiology and clinical pharmacology, and a unique hands-on perspective of translational medicine.
It is essential that the applicant is fully registered with the GMC, and desirable that they already hold a National Training Number. The clinically qualified candidate will learn many laboratory-based and clinical research techniques, which may be applicable to other research in the future. This will broaden the candidate's ability to understand and apply experimental medicine techniques in the future in the area of translational medicine.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment. This appointment also requires an Honorary Clinical Contract.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing date for applications is 11th May 2017, with an interview date to be confirmed.
Please quote reference RC11970 on your application and in any correspondence about this vacancy.
The University values diversity and is committed to equality of opportunity.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.