Applications are invited for a Research Assistant/Associate (fixed term) to investigate how herpesviruses manipulate host-cell focal adhesions during infection. The herpesvirus family comprises many highly-prevalent human and animal pathogens that can cause severe disease, especially in immunocompromised individuals. The successful applicant will join a multidisciplinary team that aims to define how herpesviruses modulate the host-cell environment to ensure efficient virus assembly and dissemination. Our recent work has identified that herpes simplex virus localises to focal adhesions of infected cells (doi: 10.1128/JVI.02196-16), and the successful applicant will lead our efforts to determine the functional consequences of this interaction for cell morphology and virus dissemination. Together, our work aims to provide the basic underpinning science that will support the next generation of medical therapies, including new antivirals and improved vaccines.
The post will be held at the Department of Pathology in the laboratory of Dr Stephen Graham, located on the Cambridge Biomedical Campus, and the research will benefit from a strong established collaboration with the laboratory of Dr Colin Crump. Candidates should have a PhD, or expect to obtain one shortly, and have a strong background in virology, cell biology or biochemistry. Where the successful applicant does not yet have a PhD, he/she will normally be under-appointed as a Research Assistant in a Research Associate post (on the understanding that he/she will be appointed as a Research Associate upon successful completion of his/her PhD). The higher Research Associate salary would be backdated to the submission date of their thesis.
Experience with immunofluorescence microscopy plus one or more of the following is essential: (i) live-cell fluorescence microscopy; (ii) purification/enrichment of focal adhesions for biochemical studies; (iii) generation of recombinant viruses and their characterisation in cell-based infection assays. Prior experience investigating herpesviruses and/or focal adhesions would be advantageous. The laboratory employs a wide range of techniques and support will be available for the successful candidate to expand their skills.
The ability to work both independently and as part of a team, coupled with excellent communication, organizational and problem solving skills are required. The duties/responsibilities of this post include developing and driving research objectives, writing up work for presentation and publication, assisting in the supervision of student research projects, and delivering seminars and occasional lectures as outlined on the Further Information Documents.
Fixed-term: The funds for this post are available for 12 months in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
General enquiries regarding this position should be directed to Irene Piper, firstname.lastname@example.org or 01223 333940 .
Please quote reference PK11935 on your application and in any correspondence about this vacancy.
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