We are seeking an individual for a postdoctoral Research Associate position in the Department of Medicine, on the Cambridge Biomedical Campus. You will join an exciting research programme focused on the disease biology of a1-antitrypsin deficiency (A1ATD) supervised by Dr. Ravi Mahadeva, in collaboration with Dr. Darren Cawkill at Apollo Therapeutics.
The work will employ cutting-edge cell biology to create an in vitro cellular model of disease to characterise both the underlying pathogenesis and mechanisms for therapeutic intervention to reverse the underlying disease phenotype. Further training will be provided as required. a1-antitrypsin is a protease inhibitor that is synthesized in the liver, secreted into plasma and circulated to the lung where it protects alveolar structures. A1ATD is caused by a well characterized genetic variant of AT (Z-AT). Resultant intracellular aggregates of Z-AT within hepatocytes and consequent reduction in secreted levels leads to the devastating liver and lung diseases of patients homozygous for the Z-form of AT.
Based on previous work in the Mahadeva group a drug discovery program has already been initiated by Apollo Therapeutics in partnership with Dr. Mahadeva at University of Cambridge, and this project represents the first to be supported by this exciting new venture (http://apollotherapeutics.com). This role represents a key part of the collaboration and brings a unique opportunity to conduct fundamental academic research into disease biology while translating this emerging understanding and expertise into an active drug discovery program. Hence an interest in learning about drug discovery and an enthusiasm for interacting with partners across both the University and through Apollo as part of the wider drug discovery team, will be essential. Publication is expected and forms an important part of this role.
Fixed-term: The funds for this post are available for 1 year in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing date for applications is 30th April 2017 with an interview date to be confirmed.
Please quote reference RC11853 on your application and in any correspondence about this vacancy.
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