Applications are invited for an enthusiastic and committed post-doctoral scientist to join a project investigating the role of lysosomal dysfunction in genetic neurological disease. This project is based in the Medical Genetics group of Dr Evan Reid at Cambridge Institute for Medical Research and is funded for up to 5 years by the Cambridge NIHR Biomedical Research Centre. Specifically the project will aim to understand the role of lysosomal abnormalities in causing axonal degeneration in a group of conditions called hereditary spastic paraplegias, with the eventual aim of developing rational therapeutic approaches for these diseases. We employ an integrated approach that combines state of the art cell biology, biochemistry, proteomics and in vivo modeling to understand these conditions.
Candidates must have experience in molecular and cell biology, and must by the time of appointment have a PhD in the biological, biochemical or biomedical sciences. They will have either published or have in preparation at least one first author primary peer-reviewed research article in a well-regarded journal. A background in membrane traffic would be very advantageous and experience in one or more of the following would be highly desirable; CRISPR-Cas genome editing, RNAi techniques, light or electron microscopy, iPSC technology.
Applicants will be expected to work closely within a highly interactive group of colleagues, to have good written and verbal communications skills and the ability to work calmly under pressure to meet deadlines.
The most recent publication related to this project is: Allison et al. "Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia." Journal of Cell Biology, in press.
Fixed-term: The funds for this post are available until 31/03/2022 in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a health assessment.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
For informal enquiries about this position please contact Dr Evan Reid on email@example.com
Please quote reference SE11842 on your application and in any correspondence about this vacancy.
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