University of Cambridge

Job Opportunities


Research Assistant/Associate

Research Assistant: £25,298 - £29,301 Research Associate: £29,301 - £38,183

We seek to recruit an ambitious and talented Research Assistant/Associate wishing to apply their molecular biology skills to identify therapeutic targets for cardiovascular disease. The successful candidate will use cutting-edge technology, including induced human pluripotent stem cells (iPSCs) and CRISPR/Cas9 genome editing.

The post will be based at the Wellcome Trust Sanger Institute under the supervision of Dr Daniel Gaffney (Group Leader at the Wellcome Trust Sanger Institute) and Dr Dirk Paul (University Lecturer in Integrative Human Genomics at the CEU). The candidate will be a member of a multi-disciplinary team consisting of molecular biologists, geneticists, and computational scientists. The project builds on recent initiatives at the Sanger Institute to generate large numbers of human iPSCs (HipSci,

The aim of the project is to identify genes and pathways relevant for atherosclerosis, the major cause of cardiovascular disease. The post-holder will be responsible for optimizing a cellular model based on iPSC-derived macrophages and characterizing these cells on the cellular and molecular level following the stimulation with a range of atherogenic agents. In addition, the successful candidate will validate selected candidate genes in these cells using CRISPR/Cas9 genome-editing methods.

Key duties:

  • Plan and conduct research experiments
  • Analyse and interpret the findings of own research
  • Help generate original ideas based on research outcomes
  • Conduct literature and database searches and integrate results into own research goals
  • Contribute to the preparation of research reports and publications
  • Present research progress and outcomes to colleagues
  • Actively participate in group meetings
  • Liaise with colleagues and develop both internal and external collaborations

Essential skills:

  • A BSc in molecular biology or related discipline or equivalent experience
  • Experience and excellent practical skills in human cell culture techniques
  • Experience in the application of a range of molecular biology methods
  • Excellent organization and record-keeping skills
  • Ability to work both independently and as part of a team
  • Ability to communicate effectively with team members and collaborators
  • Experience and understanding of biological safety regulations and procedures

Desirable skills:

  • Experience in handling induced pluripotent stem cells (iPSCs)
  • Experience in flow cytometry
  • Experience with CRISPR/Cas9 genome-editing techniques
  • Working knowledge of pathobiology of cardiovascular diseases

The funds for these posts are available until 30th April 2020

Appointment at research associate is dependent on having a PhD (or equivalent experience), including those who have submitted but not yet received their PhD. Where a PhD has yet to be awarded appointment will initially be made at research assistant and amended to research associate when the PhD is awarded.

Location: This post will be based at the Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA (

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be made to Liza Clarke ( or telephone 01223 748622.

Closing date: 11th April 2017

Interview Date: Week 24th April 2017

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please quote reference RH11696 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information

Apply online