DNA repair is crucial in all living cells. Unrepaired DNA lesions can terminate gene transcription, leading to mutations, cell death and disease. Repair defects are often linked to cancer and/or progressive neurological disorders (see Khoronenkova & Dianov, PNAS, 2015; Khoronenkova et al., Mol Cell, 2012).
We are looking to recruit a highly motivated and enthusiastic Postdoctoral Research Associate to investigate mechanistic links between deficiencies in the DNA damage response and progressive neurodegenerative diseases. In particular, we are interested in the neurodegenerative phenotype of the multisystem disorder Ataxia Telangiectasia. The project will use differentiation of patient-derived induced pluripotent stem cells, CRISPR/Cas9 editing and state-of-the-art biochemical and proteomic approaches.
The post holder will join the laboratory of Dr Svetlana Khoronenkova at the Department of Biochemistry, University of Cambridge, United Kingdom.
Applicants should have a PhD (DPhil) in Biochemistry or Molecular/Cell Biology and a strong biochemical background. Previous experience in the fields of stem cell biology and/or DNA repair would be an advantage.
For informal enquiries please contact Dr Svetlana Khoronenkova at firstname.lastname@example.org
Fixed-term: The funds for this post are available for 24 months in the first instance.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Any enquires regarding the application process can be directed to Adriana Dote (email@example.com).
Please quote reference PH11406 on your application and in any correspondence about this vacancy.
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