University of Cambridge

Job Opportunities


Postdoctoral Research Associate in heterochromatin changes in DNA/viral silencing

We are seeking an enthusiastic, motivated individual for a Wellcome Trust funded postdoctoral position in the group of Professor Paul Lehner at the Cambridge Institute of Medical Research on the Cambridge Biomedical Campus. You will join an exciting research programme using genetic and proteomic approaches to characterise the mechanism of action of the recently identified HUSH transcriptional repressor complex which deposits the H3K9me3 repressive mark and is responsible for the chromatin-mediated repression of cellular transgenes and newly integrated retroviruses (Tchasovnikarova IA et al Science. (2015) 348:1481-5; Timms RT et al Cell Reports (2016) 17(3):653-659; Greenwood et al eLife (2016;5:e18296)

This post will involve the use of cutting edge genetic, biochemical and proteomic techniques to study the mechanism of HUSH-mediated silencing. Candidates must have a PhD, with experience in the chromatin field, in chromatin biochemistry and cell biological techniques. Quantitative and analytical skills, as well as expertise in bioinformatics are also desirable. If you have an excellent background in biological sciences, have published in high impact journals, are prepared to face intellectual challenges and wish to develop your scientific skills, we would like to hear from you.

Applicants should have excellent organisation and communication skills, and work well as part of a team.

Funds for this position are available for 3 years in the first instance for immediate start, applications from individuals with a later start date will also be considered.

For further details please see .

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

For informal enquires please contact Prof Paul Lehner via email (

Please quote reference SC10695 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information

Apply online